Lithium treatment and chronic kidney disease progression
Bipolar Disorder (BD) is a severe psychiatric disorder requiring life-long management, often spanning decades with onset in adolescence or early adulthood. Lithium can be an effective treatment, but is associated with tubular and glomerular kidney damage. Approximately 30% of patients taking lithium long-term will be diagnosed with early stage chronic kidney disease (CKD). Patients are generally advised to discontinue lithium if CKD stage 3 is reached, but there are very few resources available to inform this decision.
Cambridgeshire and Peterborough NHS Foundation Trust service users aim to learn more about the implications of long-term lithium use. Cambridge Clinical Informatics have approved our request to begin this project with a review of anonymised clinical data to better understand longitudinal kidney function in patients prescribed lithium.